粪菌移植治疗肝性脑病,到底是谁在起作用
Review
FecalMicrobiotaTransplantationforTreatingHepaticEncephalopathy:ExperimentalandClinicalEvidenceandPossibleUnderlyingMechanisms
粪菌移植治疗肝性脑病最新进展
Summary:
Gutmicrobiotachangesplayakeyroleinthepathogenesisofhepaticencephalopathy(HE).Fecalmicrobiotatransplantation(FMT)isanefficientwaytomanipulatethegutmicrobiota.SuccessfulclinicalapplicationofFMTfortreatingHEwasfirstreportedin.ThisreviewcollectstheexperimentalandclinicalevidencethatsupportstheuseofFMTinthetreatmentofHE.PossibleunderlyingmechanismsofFMTtreatingHEincluderestorationoftheimpairedgut-liver-brainaxis,aswellasreductionofammoniaproduction,systemicinflammationandblood-brainbarrierpermeability.
Fig.1.PossibleunderlyingmechanismsofFMTfortreatingHE.中文简介：
肠道菌群在肝性脑病的发生发展中发挥重要作用。粪菌移植是调节肠道菌群的有效手段，年首次被报道成功治疗肝性脑病患者。本文综述了粪菌移植用于治疗肝性脑病的动物实验和临床试验证据，并提出可能的作用机制包括修复受损的肠-肝-脑轴，减少氨的生成、全身炎症和血脑屏障透过性等。Wen-RuiXie,Xiao-YaYang,HarryHua-XiangXia,Xing-XiangHe.FecalMicrobiotaTransplantationforTreatingHepaticEncephalopathy:ExperimentalandClinicalEvidenceandPossibleUnderlyingMechanisms.JournalofExploratoryResearchinPharmacology.;3(4):-.doi:10./JERP...点击“阅读原文”
